Individualised Growth Response Optimisation (IGRO): A Multi-Language Software Medical Device to Predict Growth Response in Children Treated With Growth Hormone (GH)
نویسندگان
چکیده
منابع مشابه
Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency.
OBJECTIVES GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD. SUBJECTS AND METHODS Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian pu...
متن کاملFive-year response to growth hormone in children with Noonan syndrome and growth hormone deficiency
BACKGROUND Noonan syndrome (NS) is an autosomal dominant disorder characterized by specific features including short stature, distinctive facial dysmorphic features, congenital heart defects, hypertrophic cardiomyopathy, skeletal anomalies and webbing of the neck. Molecular screening has shown that the majority of individuals with NS have a mutation in the PTPN11 gene. Noonan syndrome children ...
متن کاملGrowth hormone (GH) provocation tests and the response to GH treatment in GH deficiency.
OBJECTIVE To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD). SUBJECTS A total of 337 prepubertal GHD patients aged <10 years from the UK Pharmacia KIGS database (GH response to provocation test <20 mU/l). OUTCOME MEASURE Annual change in height standard deviation score (SDS) (revi...
متن کاملA new and accurate prediction model for growth response to growth hormone treatment in children with growth hormone deficiency.
OBJECTIVE To identify parameters which predict individual growth response to recombinant human GH (rhGH) therapy and to combine these parameters in a prediction model. DESIGN Fifty-eight prepubertal patients with GH deficiency (17 females) participated in this prospective multicenter trial with 1 year of follow-up. METHODS Auxological measurements, parameters of GH status and markers of bon...
متن کاملGrowth parameters and predictors of growth in short children with and without growth hormone (GH) deficiency treated with human GH: a randomized controlled study.
Seventy-seven prepubertal short children with heights below the third centile for age and gender were divided into three groups according to their peak GH response to clonidine and insulin provocation. Group (I) included 30 children with peak GH response < 7 micrograms/l, group (II) included 19 children, with GH peak response between 7 and 10 micrograms/l, and group (III) included 24 children w...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2014
ISSN: 1098-3015
DOI: 10.1016/j.jval.2014.08.1764